中医药
样例:中药指纹图谱质控技术的意义和作用
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- ed the past. But in view of traditional Chinese medicine, the control of indicator components is difficult to really control the efficacy of traditional Chinese medicines. Chinese dialectical therapy is in accordance with the ingredients instead of some certain chemical component. Ephedrine and ephedra, glycyrrhizic acid and glycyrrhiza, ginsenoside and ginseng, etc., are two different things in view of traditional Chinese medicine.
The efficacy of “invigorating qi”, “activating blood”, “warming interior”, “stimulating surface”, “nourishing yin”, “strengthening spleen”, etc. of traditional Chinese medicines are the results of overall effects of the internal substance group in Chinese herbal medicine pieces or patent medicine prescriptions. The whole situation of the internal substance group, including the number of substances, the mass of substances and the difference of composition proportions, will has an impact on the efficacy. There is a theory saying that “the prescription could be initiated, while the amount could not” in traditional Chinese medicine, that is to say, the efficacy of prescription depends not only on the ingredients that make up the prescription, but also on the absolute amount and compatibility ratio of each ingredient. Therefore, the composition of the prescription could be initiated, but the amount of each ingredient is the core secret of the technology, could not be announced. For example, the surface stimulator “remulus cinnamomi decoction” in the Zhang Zhongjing’s treatise on febrile diseases is composed of remulus cinnamomi, peony, ginger, prepared licorice and jujube; only by doubling the amount of peony and adding maltose, it becomes a “Xiaojianzhong decoction” that is deficiency-reinforcing, cold-dispelling and Jianzhong (spleen and stomach) -warming. As a result, to control the efficacy of traditional Chinese medicine should not be focused on some certain one or two components, but on the overall substance group in the prescription.
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During the development of traditional Chinese medicines up to today, the fingerprint quality control technology of Chinese patent medicines has become a key technology that affects the overall progress of this industry. Studies on its application have an important practical significance of ensuring the efficacy of Chinese patent medicines, increasing the overall level of traditional Chinese medicine industry, inducing agricultural modernization of traditional Chinese medicines and promoting traditional Chinese medicine to the world.
1. Usage of the fingerprint quality control technology is necessary for ensuring the efficacy of Chinese patent medicines and achieving the modernization of traditional Chinese medicines
From the middle of 1950s until now, fundamental changes have taken place in the dosage forms and production methods of Chinese patent medicines. Tablets, granules, oral liquid and other modern forms have replaced “bolus, powder, plaster and pellet” and taken the dominant position. The extracts have also replaced raw material powder as the main materials for preparations. There have been hundreds of large-scale and mechanized industrial enterprises of Chinese patent medicines that have an annual yield of more than 100 million yuan, in which the top three have the annual yield of more than1 billion yuan. At the same time, since 1958, medicines have been introduced widely to solve the supply shortages in many regions and the idiomaticity of a large number of medicines is significantly watered down. All these great changes indicate that the traditional foundation of quality stability of Chinese patent medicines is no longer suitable. The industry of Chinese patent medicines, similar to all the other industries over the world, develops from handicraft small-scale production to industrial large-scale production, at the same time, the quality control of products should also transit from relying on the experience of the process to the afterward testing. Today, the stability of the efficacy of Chinese patent medicines must be controlled with testing based on the internal quality standards of modernized products.
With the continuous progress of modern chemical analysis technology within more than 30 years, more and more research means and methods used on the study of internal chemical components of Chinese herbal medicines and Chinese patent medicines, which were getting better and better. The internal components known from research and the measurement methods were used in controlling the quality and making corresponding testing standard, and great prog上一页 [1] [2] [3] 下一页
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